Frequently Asked Questions

The following questions should help clear up any confusion you might have about frequent heartburn.
What is heartburn?

Heartburn is a painful, burning sensation in the lower chest, caused by “acid reflux.” Acid from the stomach moves back (or “refluxes”) into the esophagus, often causing heartburn pain.

What is frequent heartburn?

Heartburn that occurs two or more days a week.

What are some foods associated with heartburn?

Acidic fruits such as oranges, lemons, grapefruits and tomatoes; high-fat or spicy foods; chocolate, alcohol and coffee.

What factors can increase my risk of experiencing heartburn?

There are multiple factors including but not limited to smoking, being overweight, taking certain medications, eating before bedtime and wearing tight-fitting clothing.

What makes Zegerid OTC® different?

Zegerid OTC® is the only 24 hour frequent heartburn treatment that contains two active ingredients: the leading prescription acid reducer (omeprazole), plus a second ingredient (sodium bicarbonate) that protects the omeprazole from acid in the stomach – so it can be absorbed by the body and get right to work treating frequent heartburn.

Who can take Zegerid OTC®?

Zegerid OTC® is for use by adults 18 and older for the treatment of frequent heartburn (occurs two or more days a week). For more information, see our full product label.

What's the sodium content in Zegerid OTC®?

One Zegerid OTC® capsule (daily dose) contains 303 mg of sodium. This amount is comparable to the amount of sodium in two slices of white bread (300mg). Ask a doctor before use if you have a sodium-restricted diet.

What's a PPI?

Proton Pump Inhibitors (PPIs), such as Zegerid OTC®, are medicines specifically indicated for treating frequent heartburn. They are highly effective because they block acid production at the source by deactivating acid pumps in your stomach. And PPIs only need to be taken once a day for 14 days.

What's the difference between prescription Zegerid® and Zegerid OTC®?

From an active ingredient perspective, there is no difference between Zegerid OTC® 20mg capsule and prescription Zegerid® 20 mg capsule. While they contain the same active ingredients, the dosage strengths and indications differ between prescription Zegerid® and Zegerid OTC®. Zegerid OTC® is available in a 20 mg strength and is indicated for frequent heartburn. Prescription Zegerid® is available as both 20 mg and 40 mg strengths, and is indicated for conditions which require a doctor's diagnosis and treatment.

Is Zegerid® still available for prescription?

Yes. Physicians will still be able to prescribe Zegerid® as appropriate.

For more information on prescription Zegerid®, visit

Where can I buy Zegerid OTC®?

Zegerid OTC® capsules are available over the counter in stores nationwide, including drug stores, grocery stores, and mass retailers.

Zegerid OTC Box

*It's possible with Zegerid OTC. Use as directed for 14 days for treating frequent heartburn.
Zegerid OTC may take 1-4 days for full effect, although some people get complete relief within 24 hours.

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